The cloud extended about 3200km from Jamaica to well past Barbados in the eastern Caribbean, and 1200km from the Turks and Caicos Islands in the northern Caribbean down south to Trinidad and Tobago.
"It's very impressive," said Alex DaSilva, lead hurricane expert with AccuWeather.
The hazy skies unleashed sneezes, coughs and watery eyes across the Caribbean, with local forecasters warning that those with allergies, asthma and other conditions should remain indoors or wear face masks if outdoors.
The dust concentration was high, at .55 aerosol optical depth, the highest amount so far this year, said Yidiana Zayas, a forecaster with the National Weather Service in San Juan, Puerto Rico.
The aerosol optical depth measures how much direct sunlight is prevented from reaching the ground by particles, according to the US National Oceanic and Atmospheric Administration.
The plume is expected to hit Florida, Louisiana, Alabama and Mississippi late this week and into the weekend, DaSilva said.
However, plumes usually lose most of their concentration in the eastern Caribbean, he noted.
"Those islands tend to see more of an impact, more of a concentration where it can actually block out the sun a little bit at times," he said.
The dry and dusty air known as the Saharan Air Layer forms over the Sahara desert in Africa and moves west across the Atlantic Ocean starting around April until about October, according to NOAA.
It also prevents tropical waves from forming during the Atlantic hurricane season, which runs June 1 to November 30.
In June 2020, a record-breaking cloud of Sahara dust smothered the Caribbean.
The size and concentration of the plume had not been seen in half a century, prompting forecasters to nickname it the "Godzilla dust cloud".