Geelong (8-1) moved into top spot, at least temporarily, with a crushing 14.12 (96) to 5.3 (33) home win over GWS (1-8) at GMHBA Stadium.
Jaqueline Parry and Aishling Moloney each kicked four goals and took 19 marks between them, with Geelong scoring the first 46 points of the game.
In Melbourne, bottom-of-the-ladder St Kilda (1-8) became the last team this season to win a game, beating fellow stragglers Collingwood 5.9 (39) to 5.7 (37) at RSEA Park.
After scoring just one point last week and tallying five behinds in the first half on Saturday, the Saints kicked five second-half goals in Dal Santo's final game, after it was announced on Friday he was standing down.
At Alberton Oval, Port Adelaide (4-5) stayed in the finals race with a 3.8 (26) to 3.4 (22) home victory over West Coast (4-5), with both teams a win behind eighth-placed Fremantle, who play North Melbourne on Sunday.
Port won successive games for the first time this season, but their percentage remained below West Coast, who had won four straight.
Geelong, the league's highest-scoring team, were too clinical for GWS, who slumped to an eighth consecutive loss.
The Cats were 27-0 up at quarter-time and 45 ahead at the half, with GWS providing more competition after the main break.
Georgie Prespakis was enormous for the Cats, logging a career-best 40 touches and adding 11 clearances, 24 contested possessions and 12 score involvements.
Tarni Evans kicked three goals for the Giants.
In Melbourne, Jesse Tawhiao-Wardlaw kicked two goals and Tyanna Smith had 25 touches and 12 clearances for the Saints, who ended an 11-match losing streak stretching back almost a full year.
Collingwood (1-8) kicked the only two goals of the first half, as they stretched a two-point quarter-time lead to 12 at the half.
With the wind at the backs, the Saints rallied In the third quarter kicking three straight goals and four for the term to lead by 10 points at the last change.
Ashley Centra, who gathered 25 touches for the Pies, kicked a goal In the final 30 seconds to cut the gap to two, but the Saints held on.
"I was proud of the group to just find a way today," Dal Santo said after finishing with a 23-39 win-loss record.
"We speak to our playing group about impacting and moments of impact, and what you've probably seen on the field is I haven't been impacting.
 "Anything that happens on the field obviously falls into my bucket of responsibility and I accept everything that's happened this year."
In Adelaide, both teams kicked two goals in the first half and one in the second.
Port led 15-2 in the second quarter, but the Eagles closed to within two points at halftime.
While the Eagles had more of the play in the second and third quarters, Port had several more inside-50s in the last.
Port defender Teagan Germech was a massive presence down back, racking up 12 intercepts as her team pulled off 74 tackles to 37.
Midfielder Abbey Dowrick logged 25 touches and nine clearances for Port, and Ella Roberts tallied 22 touches and six clearances for the Eagles.
