The Dockers had a point to prove heading into Sunday's clash at Victoria Park after losing to Port Adelaide, while the Magpies were well-beaten by Richmond first-up.
But after Collingwood kicked the opening point, Fremantle quickly snatched the lead and never looked back, claiming an 8.2 (50) to 4.6 (30) win.
Powerhouse Fremantle ruck Mim Strom was everywhere with 28 disposals, 28 hit-outs, nine clearances, six tackles and a goal.
Gabrielle Newton (26 disposals), Kiara Bowers (26), Aisling McCarthy (25) and Orlagh Lally (24) were also prolific, while Bella Smith (three goals) and boom recruit Eden Zanker (two goals) hit the scoreboard.
In her first AFLW game in 682 days after a horror injury run, Collingwood superstar Brianna Davey had 22 disposals, while skipper Ruby Schleicher kicked two goals.
The Dockers snatched an 11-point lead at the first change, then Zanker's first goal since a high-profile trade from Melbourne helped nudge the margin to 16 at halftime.
Fremantle led by 26 at three-quarter time, but the Magpies fought it out.
Maisie Nankivell suffered a hamstring injury in a disappointing end to an impressive display down back for Collingwood.
At Casey Fields, Melbourne produced 11 minutes of magic to remain unbeaten and defeat GWS 9.6 (60) to 1.6 (12).
Fresh off a 21-point win against Hawthorn, last year's preliminary finalists started slow but clicked into gear midway through the first quarter before midfielder Kate Hore booted their first major late in the period.
After the first break, the Demons continued to up the ante, slotting four unanswered goals in 11 minutes to take a commanding 30-point lead into halftime.
Forward Alicia Eva (one goal) gave the visitors a glimmer of hope, but the home team kicked four consecutive majors to complete the thumping.
Melbourne's (2-0) victory continues new coach Tom Wilson's perfect start to the season, as midfielders Olivia Purcell (36 disposals, four clearances), Ryleigh Wotherspoon (three goals) and Eliza McNamara (24 disposals, one goal) were prolific.
The Giants (1-1) were looking to beat the Dees for the first time since 2017, but their faltering attack cruelled their chances of getting into the game.
Midfielder Alyce Parker was busy with 26 disposals and seven clearances, while Madison Brazendale posted 21 disposals.
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