The Mongoose was filmed in Australia, with Neeson's character, war hero Ryan "Fang" Flanagan, on the run from police as he leads them on an epic cross-country chase after being wrongly accused of murder.
And the cast and crew had to navigate an unexpected challenge caused by the country's iconic animal, particularly when filming the car scenes.
"We saw a lot of them, yeah. Especially at dusk, driving back from set. It could be very dangerous. You don't know when they're going to hop across the road," Neeson, 74, told People.
Director Mark Vanselow, who previously worked as Neeson's stunt double, shared that filming the adrenaline-filled car chase scene did not go smoothly.
"We had a track that we were doing some of the car action on, and the kangaroos were everywhere," he said.
"So we had to watch out for them and make sure they didn't hop in front of the vehicles while we were shooting."
The marsupials threatened to cause a major continuity error, given The Mongoose is set in Kentucky, Arkansas and Texas in the United States.
"And especially because we shot it in Melbourne and Melbourne surrounds. The movie's supposed to be set in America. So to have a kangaroo in shot, no, that wouldn't be good," Neeson said.