The Big Bang Theory star was married to former tennis player Ryan Sweeting from December 2013 to September 2015 but it was following her second divorce – from Karl Cook – in 2022 that she really struggled.
"I had like the crazy story when this is a handful of years ago, when I said that I was going through my divorce... it was the premiere of the second season of Flight Attendant," she said on The Drew Barrymore Show.
"I woke up that morning, I was so depressed and so sad I couldn't even breathe, and I was just lying on the floor. I literally thought I was gonna die, I really did.
"I said, 'What am I doing?' And it was like the worst morning of my life, but knowing the night was coming, it was supposed to be the best night of my life. It's so crazy those things sometimes happen at the same time.
"I couldn't get up. I'm like, 'I can't go. I can't go anywhere.' I just blew up my life. My life's over. I truly thought that."
Cuoco, 40, also vowed at the time she would never wed again but everything changed when she met current fiance Tom Pelphrey just three weeks later and went on to welcome daughter, Matilda Carmine Richie Pelphrey the following year.
"(I thought I was) never getting married again, never gonna have kids," she said.
"I knew when I was lying on that floor in my house, I thought, 'Oh my God, this is what they talk about. This is the lowest point I could get'.
"That's, like, supposed to be the best night ever of my career, and I literally saw my soul leave my body. It still chokes me up because I can remember it so clearly, but it made me a whole new person."
Cuoco has no regrets about her change of heart, after getting engaged to Ozark actor Pelphrey in August 2024.
"You know what, guys, sometimes you just change your mind and that's okay," she said.
"You probably didn't know I was lying on the floor before my premiere, ready to die ... But it takes a long time to figure that out and a lot of forgiveness."
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