The 64-year-old comedian and actor lost out on the Best Supporting Actor Oscar to Little Miss Sunshine's Alan Arkin in 2007 and admitted he was annoyed that he got dressed up and attended because he "would usually not go to award shows".
Speaking in new Netflix documentary Being Eddie, he said: "Not winning the Oscar or not winning anything is not the mindf*** for me. The mindf*** for me is that I get dressed and come to the thing, 'cause I would usually not go to award shows."
"That's... whenever I lose, I'm like, 'These motherf****** made me come all the way down.' I could have f***ing lost at home. I'm all in the f***ing tuxedo. What a... a waste of time. I'm never, like, 'Oh, I didn't win.' I'm like, 'Hey, make me come down here for nothing?'
"It's always wonderful to win stuff, but if I don't win, I don't give a f***. I still come home, and it's... I'm still Eddie in the morning."
Meanwhile, Murphy recently insisted he wasn't motivated by accolades and recognition, and doesn't "think about winning trophies".
"What's on my mind is just doing good stuff and only doing stuff that I'm going to have fun doing," Murphy told The Hollywood Reporter:
"I don't think about winning trophies. I got a bunch of trophies. I got everything but an Oscar, and I'm not like, 'This is going to get the Oscar'.
"The fact of the matter is, if I never win an Oscar, eventually they'll give me one of those honorary Oscars when I'm 90 years old.
"If they made me wait that long, I'm going to wear a sky blue tuxedo, and when they give me the Oscar, I'm going to urinate on myself while I'm giving a speech!"
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